HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chlorobenzaldehyde → 1-Methyl-4-[4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyrid-2-yl-methoxy]piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chlorobenzaldehyde | HCID 6996 | — |
| Reactant | Methyl 3-aminocrotonate | HCID 643918 | — |
| Reactant | Ethyl 4-(1-methylpiperid-4-yloxy)acetoacetate | HCID 20214984 | — |
| Product | 1-Methyl-4-[4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyrid-2-yl-methoxy]piperidine | HCID 20214961 | — |
Reaction Steps
Reaction of 2-chlorobenzaldehyde, ethyl 4-(1-methylpiperid-4-yloxy)acetoacetate and methyl 3-aminocrotonate according to the method of Example 22(ii) gave the title compound which was used directly in the next stage.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04647565 |
| Source dataset | uspto-grants-1987_03 |
| ORD ID | ord-1c4ec2167b954f8f8a203e79514e6bc4 |
| Source note | uspto-grants-1987_03 |