HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 20138923, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Bicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile, 4-methoxy- | HCID 12238660 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 20138923 | HCID 20138923 | — |
Reaction Steps
A solution of 1-cyano-5-methoxybenzocyclobutene (47.3 ml) in THF (300 ml) is added dropwise to a stirred suspension of NaH (23.8 g, 60% in mineral oil) and methyl iodide (37 ml) in THF (300 ml) under nitrogen and the reaction mixture is stirred at RT for three hours. H2O is added to the reaction mixture which is diluted with diethyl ether, washed with water, 10% aq. sodium sulphite, sat'd sodium chloride, dried, filtered and the filtrate evaporated in vacuo affording the desired product as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04647559 |
| Source dataset | uspto-grants-1987_03 |
| ORD ID | ord-8e875d6d17e64a8fa8636ba93a67316d |
| Source note | uspto-grants-1987_03 |