Ammonia → HCID 13782920, compound

HRID 1905788Notes

Reaction equation

HRID 1905788 reaction equation
[NH3:1].C[CH:3]1[CH2:8][CH2:7][CH:6]([CH3:9])[CH2:5][C:4]1=[O:10].O=O.[CH3:13]O>>[C:9]([CH2:6][CH:7]([CH3:13])[CH2:8][CH2:3][C:4](=[O:10])[CH3:5])#[N:1]

Participants

5

Reactant 4

HCID 222AmmoniaHCID 887MethanolHCID 977OxygenHCID 5230552,5-Dimethylcyclohexanone

Product 1

HCID 13782920HCID 13782920, compound

Procedure

A solution of 2 ml of NH3 in 50 ml of methanol is charged into an airtight container fitted with a gas inlet tube and mechanical stirrer. To this solution is added with stirring 0.015 g of CuCl2 2H2O and 1.25 g of 2,5-dimethyl cyclohexanone. Stirring is continued until all solids had dissolved. The container is pressurized with oxygen, and allowed to sit at room temperature for 18 hours. The methanol solvent is removed by rotary evaporator and the product extracted in ether. The ether layer is concentrated. GLC analysis confirmed the presence of 1-cyano-2-methyl-5-ketohexane.

Workup

  1. customfitted with a gas inlet tube and mechanical stirrer
  2. additionTo this solution is added
  3. dissolutionhad dissolved
  4. customThe methanol solvent is removed by rotary evaporator
  5. extractionthe product extracted in ether
  6. concentrationThe ether layer is concentrated

Sources & evidence

ORD record
ord-aefa45f2a200466d9bb948204af1680e
Source dataset
uspto-grants-1987_03
Patent number
US04647686

Reaction notes

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