Hydrochloric Acid → HCID 53996374, compound

Participants

Reaction Steps

To 4-[4-(1-methylpropoxy)phenyl]-2-butanone O-ethyloxime (2.63 g, 10.0 mmol) in 30 ml of ethanol is added sodium cyanoborohydride (2.00 g, 38.1 mmol) and methanolic 2N HCl is added throughout the reaction to maintain pH at 3. The reaction temperature is maintained at 15°-20°. After ca. 2 hours, the solvent is removed under vacuum. The mixture is made basic by the addition of 10% sodium hydroxide, followed by water and ether, and is extracted with ether. The combined organic phases are washed with water and with brine, dried and filtered and the solvent is removed in vacuo to give N-ethoxy-1-methyl-3-[4-(1-methylpropoxy)phenyl]propylamine, MS m/e 265 (M ).

Provenance & Evidence