HuagongsheHuagongshe Chemistry Print Report · For research reference only
4,6-Dichloro-5-nitro-2-phenylpyrimidine → 4,6-Dichloro-2-phenylpyrimidin-5-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4,6-Dichloro-5-nitro-2-phenylpyrimidine | HCID 100644 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ether acetate | HCID 21226428 | — |
| Product | 4,6-Dichloro-2-phenylpyrimidin-5-amine | HCID 736673 | 72.5% |
Reaction Steps
27.0 g of 4,6-dichloro-5-nitro-2-phenylpyrimidine are hydrogenated in ether acetate at room temperature by treatment with Raney nickel. The catalyst is afterwards separated and the reaction solution is concentrated by evaporation. Crystallisation of the residue from petroleum ether then yields 17.4 g of 5-amino-4,6-dichloro-2-phenylpyrimidine, m.p. 143°-144° C. (compound No. 1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04648896 |
| Source dataset | uspto-grants-1987_03 |
| ORD ID | ord-0585826f0ec546e39554c0e3decd9b03 |
| Source note | uspto-grants-1987_03 |