2-(Dimethylamino)ethanol → N,N1-Dimethyl-S-(2-dimethylaminoethyl)isothiourea

HRID 1905864Notes

Reaction equation

HRID 1905864 reaction equation
[CH3:1][N:2]([CH3:6])[CH2:3][CH2:4]O.[CH3:7][N:8]([CH3:12])[C:9]([NH2:11])=[S:10]>>[CH3:7][N:8]([CH3:12])[C:9](=[NH:11])[S:10][CH2:4][CH2:3][N:2]([CH3:6])[CH3:1]

Participants

3

Reactant 2

HCID 79022-(Dimethylamino)ethanolHCID 30341921,1-Dimethyl-2-thiourea

Product 1

HCID 86736996N,N1-Dimethyl-S-(2-dimethylaminoethyl)isothioureaYield 128%

Procedure

A mixture of 2-dimethylaminoethanol (2.23 g), N,N1 -dimethylthiourea (2.6 g) and aqueous hybrobromic acid (48%, 20 ml) was boiled under reflux for 50 hours and evaporated to dryness. The residue was recrystallised from a mixture of methanol and ethanol to give the dihydrobromide of the title compound (5.6 g) m.p. 198°-199°.

Workup

  1. temperatureunder reflux for 50 hours
  2. customevaporated to dryness
  3. customThe residue was recrystallised from a mixture of methanol and ethanol

Sources & evidence

ORD record
ord-b6ad22fc3fe442ae92b8ea91b5e75d87
Source dataset
uspto-grants-1987_03
Patent number
US04649138

Reaction notes

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