Water → HCID 20213358, compound

Participants

Reaction Steps

To a suspension of 1,3-dimethyl-6-(4-methoxy-3-methylthiophenyl)-1,2,3,4-tetrahydropyrimidine-2,4dione (6.5 g) in pyridine (60 ml) was added phosphorus pentasulfide (4.95 g), and refluxed for 8 hours. After cooled, the mixture was poured into water (600 ml). The precipitates were collected, dried in the air, and refluxed with ethanol (150 ml) for 2 hours. After cooled, resulting precipitates were filtered, and washed with ethanol and diisopropyl ether, to give 1,3-dimethyl-6-(4-methoxy-3-methylthiophenyl)-1,2,3,4-tetrahydro-4-thioxopyrimidin-2-one (5.47 g). mp 174°-176° C.

Provenance & Evidence