Ethyl bromoacetate → HCID 13608185, compound

Participants

Reaction Steps

To a suspension of 3,4-dihydro-6-(3,4-dimethoxyphenyl)-3-methyl-4-(2,4,6-trimethylphenylimino)-2(1H)-pyrimidinone (26.1 g) in N,N-dimethylformamide (350 ml) were added potassium tert. butoxide (9.2 g) and ethyl bromoacetate (13.7 g) at room temperature. The mixture was stirred overnight. After neutralization with diluted hydrochloric acid, the mixture was evaporated and chromatographed on silica gel using chloroform. Fractions containing the object compound were evaporated and the residue was triturated in ethanol to give 3,4-dihydro-6-(3,4-dimethoxyphenyl)-1-ethoxycarbonylmethyl-methyl-4(2,4,6-trimethylphenylimino)-2(1H)pyrimidinone (15.3 g). mp. 112°-113° C.

Provenance & Evidence