反应详情

Ethyl 3-(2-chloro-5,6-dimethyl-3-pyridyl)acrylate (32.7 g) in ethanol (500 ml) was hydrogenated at 25°-30° and 344 kPa using palladium-on-charcoal catalyst (5%, 3 g). The mixture was filtered and the filtrate was evaporated to an oil which was partitioned between chloroform and 2N hydrochloric acid. The aqueous phase was made basic with aqueous sodium hyroxide, extracted with chloroform and the chloroform extracts were evaporated to give ethyl 3-(5,6-dimethyl-3-pyridyl)propionate (21.8 g, 80%) as an oil.

1. customwas hydrogenated at 25°-30°
2. filtrationThe mixture was filtered
3. customthe filtrate was evaporated to an oil which
4. customwas partitioned between chloroform and 2N hydrochloric acid
5. extractionextracted with chloroform
6. customthe chloroform extracts were evaporated