HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Methoxypyridine-3-carbaldehyde → Ethyl 3-(6-methoxy-3-pyridyl)acrylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Methoxypyridine-3-carbaldehyde | HCID 3364576 | — |
| Reactant | Propanedioic acid, monoethyl ester | HCID 3595298 | — |
| Catalyst | Piperidine | HCID 8082 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | Ethyl 3-(6-methoxy-3-pyridyl)acrylate | HCID 53930754 | 79.2% |
Reaction Steps
A mixture of 6-methoxypyridine-3-carboxaldehyde (2.34 g), monoethyl malonate (4.51 g), pyridine (12 ml) and piperidine (6 drops) was heated under reflux for 5 hours and was evaporated to an oil. This oil was partitioned between ether and dilute aqueous ammonia. The ether layer was washed with water and evaporated to an oil which crystallised on standing to give ethyl 3-(6-methoxy-3-pyridyl)acrylate (2.8 g, 79%) m.p. 49°-52°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04649141 |
| Source dataset | uspto-grants-1987_03 |
| ORD ID | ord-364a3ff8ffc24e1b8e04770ec801929c |
| Source note | uspto-grants-1987_03 |