HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Benzyl-3-pyrrolidinone → 1-Benzyl-3-methylpyrrolidin-3-OL
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Benzyl-3-pyrrolidinone | HCID 69890 | — |
| Reactant | HCID 178418373 | HCID 178418373 | — |
| Product | 1-Benzyl-3-methylpyrrolidin-3-OL | HCID 18629648 | — |
Reaction Steps
1-Benzyl-3-pyrrolidone [J. Org. Chem., 30., 740 (1965)] was allowed to react with methylmagnesium iodide to give 1-benzyl-3-hydroxy-3-methylpyrrolidine as an oil, b.p. 106° C./0.5 mmHg. This compound was treated with a mixture of acetonitrile and concentrated sulfuric acid under ice cooling to give 3-acetylamino-1-benzyl-3-methylpyrrolidine, m.p. 105°-106° C. This compound was hydrogenated catalytically in the presence of 5% palladium-carbon to give 3-acetylamino-3-methylpyrrolidine as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04649144 |
| Source dataset | uspto-grants-1987_03 |
| ORD ID | ord-c2d74861b553463e9856bc3c698246a8 |
| Source note | uspto-grants-1987_03 |