Phosphorus oxychloride → HCID 178526525, compound

Participants

Reaction Steps

A mixture to 2-hydroxy-4-(4-nitro-phenyl)-1H-imidazole (15 g) and phosphorous oxychloride (750 ml) was refluxed, while stirring, for 24 hours. The solution was then evaporated to dryness, the residue was adjusted to pH 6.5 with a H2PO4- /HPO4-- buffer, and extracted with methylene chloride. After drying, the organic solution was evaporated, and the crude product was chromatographed on silica gel to give 6.7 g of the title compound. M.p. 136°-138° C.

Provenance & Evidence