HCID 178432541, compound → HCID 178432549, compound

HRID 1905944Notes

Reaction equation

HRID 1905944 reaction equation
[CH3:1][C:2]1[NH:3][CH:4]=[C:5]([C:7]2[CH:12]=[CH:11][C:10]([NH2:13])=[CH:9][CH:8]=2)[N:6]=1.C(O)(=O)/C=C\C(O)=O.C(N[CH:26]=[N:27][C:28]1[CH:33]=[CH:32][C:31](C2N=C(C)NC=2)=[CH:30][C:29]=1OC)CC>>[C:28]1([NH:27][CH:26]=[N:13][C:10]2[CH:11]=[CH:12][C:7]([C:5]3[N:6]=[C:2]([CH3:1])[NH:3][CH:4]=3)=[CH:8][CH:9]=2)[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1

Participants

3

Reactant 2

HCID 178432541HCID 178432541, compoundHCID 178457514HCID 178457514, compound

Product 1

HCID 178432549HCID 178432549, compound

Procedure

2-Methyl-4-(4-amino-phenyl)-1H-imidazole (5 g) was added to a solution of ethyl N-phenyl-formamidate (5 g) in acetone (25 ml). After 3 hours of stirring at room temperature, the solid which separated out was filtered off and dried. The product was treated with glacial acetic acid in acetone. The acetate salt which precipitated was filtered off and dried to give 4.6 g of the title compound.

Workup

  1. customthe solid which separated out
  2. filtrationwas filtered off
  3. customdried
  4. additionThe product was treated with glacial acetic acid in acetone
  5. customThe acetate salt which precipitated
  6. filtrationwas filtered off
  7. customdried

Sources & evidence

ORD record
ord-08ad603b6ee74a9cbacbfa39d7ab5cbe
Source dataset
uspto-grants-1987_03
Patent number
US04649150

Reaction notes

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