1-(2-Hydroxyethyl)piperazine → HCID 13787505, compound

HRID 1905946Notes

Reaction equation

HRID 1905946 reaction equation
[C:1]([C:5]1[S:6][C:7]2[CH:13]=[C:12]([N:14]=[C:15]=[S:16])[C:11]([O:17][CH3:18])=[CH:10][C:8]=2[N:9]=1)([CH3:4])([CH3:3])[CH3:2].[OH:19][CH2:20][CH2:21][N:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1>CC(C)=O>[C:1]([C:5]1[S:6][C:7]2[CH:13]=[C:12]([NH:14][C:15]([N:25]3[CH2:26][CH2:27][N:22]([CH2:21][CH2:20][OH:19])[CH2:23][CH2:24]3)=[S:16])[C:11]([O:17][CH3:18])=[CH:10][C:8]=2[N:9]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 173314Cgp 20308

Product 1

HCID 13787505HCID 13787505, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent2×

Procedure

21 g (0.076 mole) of 2-tert.-butyl-6-isothiocyano-5-methoxy-benzthiazole are dissolved in 400 ml of acetone and a solution of 12 g (0.092 mole) of N-(2-hydroxyethyl)-piperazine in 40 ml of acetone is added dropwise. The mixture is stirred for 2 hours, cooled to 0°, filtered and washed with acetone, then with ether and finally with petroleum ether. 2-tert.-butyl-5-methoxy-6-{[4-(2-hydroxyethyl)-piperazin-1-yl]-thiocarbonylamino}-benzthiazole having a melting point of 161°-162° is obtained.

Workup

  1. temperaturecooled to 0°
  2. filtrationfiltered
  3. washwashed with acetone

Sources & evidence

ORD record
ord-639f655d64e34c808359f9af5ee40f50
Source dataset
uspto-grants-1987_03
Patent number
US04649149

Reaction notes

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