Acetyl chloride → HCID 13787398, compound

HRID 1905953Notes

Reaction equation

HRID 1905953 reaction equation
[CH3:1][C:2]1[S:6][C:5]([CH:7]([CH2:11][C:12]([OH:14])=[O:13])[C:8]([OH:10])=O)=[CH:4][CH:3]=1.C(Cl)(=O)C>>[CH3:1][C:2]1[S:6][C:5]([CH:7]2[CH2:11][C:12](=[O:13])[O:14][C:8]2=[O:10])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 6367Acetyl chlorideHCID 13588805HCID 13588805, compound

Product 1

HCID 13787398HCID 13787398, compoundYield 69.1%

Procedure

15.8 g of (5-methyl-2-thienyl) succinic acid was added to 75 cc of acetyl chloride and the mixture was refluxed for 1 hour 30 minutes. The excess acetyl chloride was evaporated under reduced pressure. Bidistillation of the residue provided 10 g (yield=69%) of (5-methyl-2-thienyl) succinic anhydride. Bp1=155°-160° C.

Workup

  1. temperaturethe mixture was refluxed for 1 hour 30 minutes
  2. customThe excess acetyl chloride was evaporated under reduced pressure

Sources & evidence

ORD record
ord-9f4df11d3b4844eaaf57015c44cc89eb
Source dataset
uspto-grants-1987_03
Patent number
US04649153

Reaction notes

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