Methanol → HCID 13787399, compound

Participants

Reaction Steps

A solution of 9.4 g (0.051 mole) of 2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophene-6-carboxylic acid and 0.4 g of paratoluenesulfonic acid monohydrate in 400 cc of methanol was stirred at ambient temperature for 20 hours then concentrated dry under reduced pressure. The residue was picked up with ethyl acetate. The resulting solution was washed with an aqueous solution of sodium bicarbonate then water. It was dried on sodium sulfate. After evaporation of the solvent under reduced pressure, the residue was distilled. 7.5 g (yield=74%) of methyl 2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophene-6-carboxylate was obtained. Bp0.6=107° C.

Provenance & Evidence