(5-Ethyl-2-thienyl)succinic acid → (5-Ethyl-2-thienyl)succinic anhydride

HRID 1905961Notes

Reaction equation

HRID 1905961 reaction equation
[CH2:1]([C:3]1[S:7][C:6]([CH:8]([CH2:12][C:13]([OH:15])=[O:14])[C:9]([OH:11])=O)=[CH:5][CH:4]=1)[CH3:2]>C(Cl)(=O)C>[CH2:1]([C:3]1[S:7][C:6]([CH:8]2[CH2:12][C:13](=[O:14])[O:15][C:9]2=[O:11])=[CH:5][CH:4]=1)[CH3:2]

Participants

3

Reactant 1

HCID 13588838(5-Ethyl-2-thienyl)succinic acid

Product 1

HCID 13588839(5-Ethyl-2-thienyl)succinic anhydrideYield 78%

Reagents, catalysts & solvents 1

HCID 6367Acetyl chlorideSolvent

Procedure

Ring formation of 20 g (0.088 mole) of (5-ethyl-2-thienyl)succinic acid by 90 cc of acetyl chloride, performed under the conditions of example 3, provided 14.4 g (yield=78%) of (5-ethyl-2-thienyl)succinic anhydride.

Sources & evidence

ORD record
ord-16a0aa88186f4e64b4710ac6ec4b5a2b
Source dataset
uspto-grants-1987_03
Patent number
US04649153

Reaction notes

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