2-(4-Methylthiophenyl)ethoxyacetic acid → 2-[2-(4-Methylthiophenyl)ethoxy]ethanol

HRID 1905972Notes

Reaction equation

HRID 1905972 reaction equation
[CH3:1][S:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][O:11][CH2:12][C:13](O)=[O:14])=[CH:5][CH:4]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[CH3:1][S:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:9][CH2:10][O:11][CH2:12][CH2:13][OH:14])=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 132089272-(4-Methylthiophenyl)ethoxyacetic acidHCID 21226445Aluminium lithium hydride

Product 1

HCID 132089342-[2-(4-Methylthiophenyl)ethoxy]ethanolYield 54%

Procedure

The 2-(4-methylthiophenyl)ethoxyacetic acid obtained according to the preceding paragraph was reduced with lithium aluminum hydride in a manner analogous to that described in Example 1(b) to give 1.97 g (54%) of 2-[2-(4-methylthiophenyl)ethoxy]ethanol in the form of an oil which was homogeneous according to chromatography.

Sources & evidence

ORD record
ord-98a46806ad934b769e16d501d57f4844
Source dataset
uspto-grants-1987_03
Patent number
US04649160

Reaction notes

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