HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[2-Hydroxy-3-(propan-2-ylamino)propoxy]phenol → 1-[4-[2-(4-Chlorophenethyloxy)-ethoxy]phenoxy]-3-isopropylamino-2-propanol hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[2-Hydroxy-3-(propan-2-ylamino)propoxy]phenol | HCID 182336 | — |
| Reactant | 2-[2-(4-Chlorophenyl)ethoxy]ethyl methanesulfonate | HCID 13210822 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 1-[4-[2-(4-Chlorophenethyloxy)-ethoxy]phenoxy]-3-isopropylamino-2-propanol hydrochloride | HCID 13210835 | 114.9% |
Reaction Steps
In a manner analogous to that described in the first paragraph of Example 1, from 1.08 g of 1-isopropylamino-3-(4-hydroxyphenoxy)-2-propanol and 1.42 g of 2-[2-(4-chlorophenyl)ethoxy]ethyl methanesulfonate there were obtained 1.3 g (57%) of 1-[4-[2-(4-chlorophenethyloxy)-ethoxy]phenoxy]-3-isopropylamino-2-propanol hydrochloride of melting point 99°-101° C. (from ethyl acetate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04649160 |
| Source dataset | uspto-grants-1987_03 |
| ORD ID | ord-f3d96be446314547a8eb34ab89715121 |
| Source note | uspto-grants-1987_03 |