Sulfuric Acid → Sulfuric Acid

HRID 1906037Notes

Reaction equation

HRID 1906037 reaction equation
[H][H].[CH3:3][CH:4]([OH:19])[CH:5]([OH:18])[C:6]1[N:11]=[C:10]2[C:12]([N:14]=[C:15]([NH2:17])[NH:16][C:9]2=[N:8][CH:7]=1)=[O:13].[S:20](=[O:24])(=[O:23])([OH:22])[OH:21]>[Pd]=O>[S:20](=[O:22])(=[O:21])([OH:24])[OH:23].[CH3:3][CH:4]([OH:19])[CH:5]([OH:18])[CH:6]1[NH:11][C:10]2[C:12]([N:14]=[C:15]([NH2:17])[NH:16][C:9]=2[NH:8][CH2:7]1)=[O:13]

Participants

6

Reactant 3

HCID 1118Sulfuric Acid2×HCID 178418361HCID 178418361, compound2×HCID 178469705HCID 178469705, compound

Product 2

HCID 1118Sulfuric AcidHCID 178469706HCID 178469706, compound

Reagents, catalysts & solvents 1

HCID 5083724Palladium monoxideCatalyst

Procedure

Ten milligrams of palladium oxide was dispersed into 10 ml of 5% aqueous sulfuric acid solution, and then the catalyst was activated with hydrogen gas. Then, 10 ml of 5% aqueous sulfuric acid solution containing 50 mg of biopterin was added to the above dispersion. After the catalytic reduction was conducted by agitating the resulting mixture for 3 hours under normal temperature and normal pressure in a hydrogen atmosphere, the catalyst was filtered off from the reaction mixture to give a sulfuric acid solution of tetrahydrobiopterin having a (6R)/(6S) ratio of 70/30 as measured by HPLC.

Workup

  1. additionwas added to the above dispersion
  2. filtrationthe catalyst was filtered off from the reaction mixture

Sources & evidence

ORD record
ord-66f045a23a6640148550ca9fb3902f23
Source dataset
uspto-grants-1987_03
Patent number
US04649197

Reaction notes

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