Sulfur Dioxide → Ibuprofen methyl ester

Participants

Reaction Steps

In this example, 11 g of N,N-dimethylformamide was added to 2.52 g of α-hydroxy-p-isobutylpropiophenone dimethylacetal. Then, 18 ml of sulfur dioxide and 1.1 g of chlorine were added to the mixture at -50° C. The temperature was elevated to 10° C. over 2 hours, and 20 ml of chloroform was added thereto. Subsequent post-treatment was performed in a manner similar to Example 8 to obtain 1.1 g of methyl 2-(4-isobutylphenyl)propionate.

Provenance & Evidence