HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nitrogen → 6-[(1-Carbamoyl-1,2-dimethylpropyl)carbamoyl]thieno[2,3-b]pyridine-5-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nitrogen | HCID 947 | — |
| Reactant | 2-Amino-2,3-dimethylbutanamide | HCID 9793773 | — |
| Reactant | Thieno[2,3-b]pyridine-5,6-dicarboxylic acid anhydride | HCID 13849605 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 6-[(1-Carbamoyl-1,2-dimethylpropyl)carbamoyl]thieno[2,3-b]pyridine-5-carboxylic acid | HCID 14032363 | 72% |
Reaction Steps
2-Amino-2,3-dimethylbutyramide (9.84 g, 0.076 mol) is added to a stirred suspension of thieno[2,3-b]pyridine-5,6-dicarboxylic acid anhydride (14.8 g, 0.072 mol) in THF under an inert atmosphere of N2 at room temperature. The dark solution is stirred at room temperature overnight and the resulting solid filtered off, washed with THF and air dried to give 17.35 g (72%) of 6-[(1-carbamoyl-1,2-dimethylpropyl)carbamoyl]thieno[2,3-b]pyridine-5-carboxylic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04650514 |
| Source dataset | uspto-grants-1987_03 |
| ORD ID | ord-7d6f5bf563ee450e876ec811618b1f18 |
| Source note | uspto-grants-1987_03 |