Water → HCID 13849583, compound

HRID 1906100Notes

Reaction equation

HRID 1906100 reaction equation
[CH:1]([C:4]1([CH3:26])[C:8](=[O:9])[NH:7][C:6]([C:10]2[N:15]=[C:14]3[S:16][CH:17]=[C:18]([N+:19]([O-:21])=[O:20])[C:13]3=[CH:12][C:11]=2[C:22]([O:24]C)=[O:23])=[N:5]1)([CH3:3])[CH3:2].[OH-].[Na+].O>CO>[CH:1]([C:4]1([CH3:26])[C:8](=[O:9])[NH:7][C:6]([C:10]2[N:15]=[C:14]3[S:16][CH:17]=[C:18]([N+:19]([O-:21])=[O:20])[C:13]3=[CH:12][C:11]=2[C:22]([OH:24])=[O:23])=[N:5]1)([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 13849582HCID 13849582, compound

Product 1

HCID 13849583HCID 13849583, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The ester (1.0 g, 0.00266 mol) from Example 21 is stirred in 100 mL methanol and 10 mL 10% sodium hydroxide solution for 24 hours. Water (25 mL) is added and the methanol removed in vacuo. Acidification of the aqueous layer gives a brown precipitate which upon filtration and crystallization from methanol-water has mp 260° C.

Workup

  1. customthe methanol removed in vacuo
  2. customAcidification of the aqueous layer gives a brown precipitate which
  3. filtrationupon filtration and crystallization from methanol-water

Sources & evidence

ORD record
ord-be1089cf43aa4167a282f99a7103cb1d
Source dataset
uspto-grants-1987_03
Patent number
US04650514

Reaction notes

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