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HRID1906122

反应详情

EQUATION

反应方程式

HRID 1906122 的结构方程式

REACTANTS

反应物

4
结构：CCOCC.FB(F)F
HCID8000

Ethane, 1,1'-oxybis-, compd. with trifluoroborane (1:1)

C4H10BF3O

结构：CC(C)(C)C(O)C(C)(C)C
HCID139790

2,2,4,4-Tetramethylpentan-3-ol

C9H20O

结构：O=C([O-])O.[Na+]
HCID516892

Sodium Bicarbonate

CHNaO3

结构：CC1CN1C(=O)OCc1ccccc1
HCID21895246

未命名化合物

PRODUCTS

生成物

1
结构：CC(COC(C(C)(C)C)C(C)(C)C)NC(=O)OCc1ccccc1
HCID20201216

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

N-Cbz-2-Methyl aziridine and di-t-butylmethanol are dissolved in CH2Cl2 at 0° C. under argon. Boron trifluoride etherate is added and the flask is stirred overnight. The contents are poured into saturated NaHCO3 and are extracted with ethyl acetate. The organic layer is dried over MgSO4 and evaporated to yield N-Cbz-2-amino 1-[di-(t-butyl)methoxy]propane.

WORKUP

后处理

  1. extractionare extracted with ethyl acetate
  2. dry with materialThe organic layer is dried over MgSO4
  3. customevaporated