N-Cbz-2-amino 1-[di-(t-butyl)methoxy]propane → 2-Amino 1-[di-(t-butyl)methoxy]propane

HRID 1906123노트

반응식

HRID 1906123 반응식
C([NH:11][CH:12]([CH3:24])[CH2:13][O:14][CH:15]([C:20]([CH3:23])([CH3:22])[CH3:21])[C:16]([CH3:19])([CH3:18])[CH3:17])(OCC1C=CC=CC=1)=O>CO.[Pd]>[NH2:11][CH:12]([CH3:24])[CH2:13][O:14][CH:15]([C:20]([CH3:23])([CH3:22])[CH3:21])[C:16]([CH3:18])([CH3:17])[CH3:19]

참가 물질

4

반응물 1

HCID 20201216N-Cbz-2-amino 1-[di-(t-butyl)methoxy]propane

생성물 1

HCID 139072462-Amino 1-[di-(t-butyl)methoxy]propane

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

N-Cbz-2-Amino 1-[di-(t-butyl)methoxy]propane is dissolved in CH3OH and hydrogenated over 5% Pd/C in a Paar hydrogenation apparatus. When the reaction is complete the mixture is filtered through Celite and concentrated to yield 2-amino 1-[di-(t-butyl)methoxy]propane.

후처리

  1. filtrationis filtered through Celite
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-65f9e91d781c4c6093b5612df4af00ab
출처 데이터셋
uspto-grants-1987_03
특허 번호
US04650688

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