Ammonium fumarate → L-Aspartic Acid

HRID 1906130Notes

Reaction equation

HRID 1906130 reaction equation
[C:1]([O-:8])(=[O:7])/[CH:2]=[CH:3]/[C:4]([O-:6])=[O:5].[NH4+:9].[NH4+]>O>[NH2:9][C@H:2]([C:1]([OH:8])=[O:7])[CH2:3][C:4]([OH:6])=[O:5]

Participants

3

Reactant 1

HCID 9793847Ammonium fumarate2×

Product 1

HCID 5960L-Aspartic Acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A batch type process wherein the catalyst compositions are stirred in from 0.1 to 5.0 molar (preferably 0.5 to 2.0 molar) solutions of ammonium fumarate in water at 5.0 to 10.0 pH (preferably 7.5 to 9.5 pH) for periods of 1.0 to 100 hours (preferably 8 to 48 hours) at temperatures below 60° C. (preferably 20° to 45° C.). Broadly from 0.05 to 50 g of immobilized cells, preferably from 1.0 to 15 g, are used per 1.0 mole of starting ammonium fumarate. After the conversion, the catalyst compositions may be removed by filtration or the equivalent for reuse in converting fresh batches of fumarate solutions. The product solutions are obtained in a form suitable for conventional processing to isolate the L-aspartic acid (acidification, precipitation, filtration, washing, recrystallization, drying).

Workup

  1. customAfter the conversion, the catalyst compositions may be removed by filtration
  2. customThe product solutions are obtained in a form suitable for conventional processing

Sources & evidence

ORD record
ord-9253d53e23bd476c87352d6ba9fdae87
Source dataset
uspto-grants-1987_03
Patent number
US04650755

Reaction notes

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