Diethyl Ether → HCID 178512188, compound

HRID 1906132Notes

Reaction equation

HRID 1906132 reaction equation
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:13]([OH:15])=[O:14])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:12])[NH:8][N+:9]([O-:11])=[O:10].C(OCC)C>Cl.CC(O)=O.CO>[NH2:1][C@H:2]([C:13]([OH:15])=[O:14])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:12])[NH:8][N+:9]([O-:11])=[O:10]

Participants

5

Reactant 2

HCID 3283Diethyl EtherHCID 178454200HCID 178454200, compound

Product 1

HCID 178512188HCID 178512188, compoundYield 159.2%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 22641269Acetate-hydrochloric acidSolvent

Procedure

45.4 Grams (0.1 mole) of BOC-Arg(NO2)-CHA was dissolved in 300 ml (0.6 mole) of 2N-HCl/AcOH with a small amount of MeOH, and the mixture was reacted at room temperature for 2 hours. After the reaction was completed, 300 ml of dried diethyl ether was added to the reaction mixture so as to precipitate the crystals. There was obtained 34.9 g (89.4%) of H-Arg(NO2)-CHA.HCl.

Workup

  1. customthe mixture was reacted at room temperature for 2 hours
  2. customto precipitate the crystals

Sources & evidence

ORD record
ord-c65b1387ab414d438b6c4618cd287017
Source dataset
uspto-grants-1987_03
Patent number
US04650753

Reaction notes

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