Hydrochloric Acid → HCID 13488124, compound

Participants

Reaction Steps

4-Nitro-L-phenylalanine (21 g) was dissolved in 10% NaOH (10 ml), and an ethyl ether solution of phenoxyacetyl chloride (1.7 g) and an aqueous Na2CO3 solution prepared from Na2CO3 2.7 g and water 25 ml were alternately added stepwise thereto while stirring at room temperature over 20 minutes. After that, the mixture was stirred at a room temperature for 3 hours, and then acidified with dilute HCl to precipitate the crystals. The crystals were filtered, washed with water, and re-crystallized from dioxan to obtain N-phenoxyacetyl-4-nitro-L-phenylalanine as needles having melting point: 147° C. (2.4 g).

Provenance & Evidence