HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-1-(thiophen-2-yl)ethan-1-one → HCID 12791243, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-1-(thiophen-2-yl)ethan-1-one | HCID 2776372 | — |
| Reactant | 5-Bromopyrimidin-2(1H)-one--hydrogen bromide (1/1) | HCID 12795533 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 12791243 | HCID 12791243 | — |
Reaction Steps
A suspension of 5-bromopyrimidin-2-one hydrobromide (780 mg) and 2-bromoacetylthiophene (633 mg) in triethylamine (1 ml) and ethanol (20 ml) was stirred at ambient temperature for 11/2 hours. A solution formed within 10 minutes but a suspension subsequently resulted. This was chilled in ice, and the collected solid was crystallised from acetone to give the title pyrimidinone: yield 293 mg; m.p. 173°-175° C. dec; λmaxEtOH 259.5 nm (ε 9470), 287 nm (ε 6830), 332 nm (ε 2780).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04650800 |
| Source dataset | uspto-grants-1987_03 |
| ORD ID | ord-b40156b582e4475e90be585199500c68 |
| Source note | uspto-grants-1987_03 |