5-Fluoropyrimidin-2-one → HCID 12791247, compound

Participants

Reaction Steps

A mixture of 5-fluoropyrimidin-2-one (456 mg) and 2-bromoacetylthiophene (820 mg) in triethylamine (1.33 ml) and ethanol (25 ml) was stirred at room temperature. After 2.5 h. the reaction mixture was concentrated to ca. 5 ml, diluted with ethyl acetate (300 ml) washed with water (3×50 ml), dried (MgSO4) and evaporated to a foam. This was crystallised from acetone to give the title pyrimidinone (225 mg), m.p. 183°-190° C. (dec) λmax (EtOH) 260 nm (ε10,308), 285.5 nm (ε 8,430).

Provenance & Evidence