HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Chloro-2(1H)-pyrimidinone → HCID 12791248, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Chloro-2(1H)-pyrimidinone | HCID 108578 | — |
| Reactant | 2-Bromo-1-(thiophen-3-yl)ethan-1-one | HCID 2776379 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 12791248 | HCID 12791248 | 45.2% |
Reaction Steps
A mixture of 5-chloropyrimidin-2-one (522 mg) and 3-bromoacetylthiophene (1.025 g) in triethylamine (0.84 ml) and ethanol (25 ml) was stirred at room temperature. After 1 h. the mixture was cooled to 3° C., the resulting precipitate was collected, then dried and recrystallised twice from ethanol to give the title pyrimidinone (460 mg), m.p. 227°-230° C., λmax (EtOH) 250 nm (ε 15,770), 333 nm (ε 2,690).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04650800 |
| Source dataset | uspto-grants-1987_03 |
| ORD ID | ord-7658ddd44cc44a50b871eea49243254f |
| Source note | uspto-grants-1987_03 |