Sodium Acetate → HCID 20212691, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2.21 g of the carboxyl compound obtained in Example 8 and 0.45 g of sodium acetate in 10 ml of acetic anhydride was heated at 100° C. for 2 hours, and the mixture was concentrated under reduced pressure. n-Hexane was added to the mixture and the insoluble matter was filtered off. The filtrate was concentrated to dryness to give a crude product of 3-octadecyloxy-2-succinimido-1-trityloxypropanol. This crude trityl compound in 20 ml of 70% acetic acid was heated at 100° C. for 2 hours. The reaction mixture was concentrated to dryness and the residue was purified by silica gel chromatography (chloroform-methanol=20:1) to give 1.316 g (95%) of the desired compound as a colorless powder.

Provenance & Evidence