反应详情

温度

0 °C

To a solution of 3-ethoxycarbonyl-1-benzoyl-4H-quinolizin-4-one (2.14 g) in chloroform (65 ml) was added dropwise trimethylsilyliodide (1.04 ml) at 0° C. After stirring for 30 minutes at 0° C., trimethylsilyliodide (1.04 ml) was added. After stirring for hour at room temperature, trimethylsilyliodide (1.04 ml) was added. After stirring for 2 hours at room temperature, the reaction mixture was diluted with chloroform and washed with water. After drying over magnesium sulfate, the chloroform extract was filtered and concentrated. The precipitate was washed with a cold chloroform to give 1-benzoyl-4H-quinolizin-4-one-3-carboxylic acid (1.252 g) as yellow crystals.

1. stirringAfter stirring for hour at room temperature
2. stirringAfter stirring for 2 hours at room temperature
3. washwashed with water
4. dry with materialAfter drying over magnesium sulfate
5. extractionthe chloroform extract
6. filtrationwas filtered
7. concentrationconcentrated
8. washThe precipitate was washed with a cold chloroform