HCID 11299248, compound → HCID 86741348, compound

Participants

Reaction Steps

An intimate mixture of 1-acetyl-2,3-dihydro-1H-indole-5-acetic acid, methyl ester (2.96 g) and 10% palladium on charcoal (50% moistened with water) (6.18 g) was heated at 200° for 11/2 h and the resulting solid was continuously extracted with chloroform (Soxhlet) for 2 h. Evaporation of the solvent gave an oil (1.21 g), which was purified by column chromatography on silica (Merck 7734; 138 g). Elution with ether-petroleum ether (1:1) gave the title compound (0.99 g) as an oil which was used in the next stage without further purification.

Provenance & Evidence