Pyridine → HCID 20212771, compound

Participants

Reaction Steps

To a mixture of 1,2-bis(4-hydroxymethyl-3,5-dioxopiperazin-1-yl)ethane (0.32 g, 1.0 m mol) and pyridine (9 ml), cyclohexanecarbonyl chloride (0.3 ml, 2.2 m mol) was added gradually, and then the mixture was stirred for 12 hours at room temperature. The reaction mixture was diluted with ethyl acetate (100 ml) and was washed with 10% sulfuric acid solution and successively with water and was dried. The crude product obtained by removing the solvent under reduced pressure from the above mixture was purified by silica gel column chromatography (ethyl acetate: chloroform=2:1, Rf value=0.6) to give the oily titled compound (0.16 g, yield 30%).

Provenance & Evidence