反应详情

A mixture of 3.5 g of ethyl (R/S)-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)acetate and 11.2 g of 1,2-ethylenediamine is left to stand at room temperature for 20 hours. The excess 1,2-ethylenediamine is evaporated in vacuo. The residue is dissolved in 40 ml of hot acetonitrile and stirred at room temperature for 2 hours and then in an ice-bath for 1 hour. By filtration there is isolated N-[2-(amino)ethyl]-2-(3-hydroxy-2oxo-1-pyrrolidinyl)acetamide of melting point 110°-112°.

1. waitis left
2. customThe excess 1,2-ethylenediamine is evaporated in vacuo
3. dissolutionThe residue is dissolved in 40 ml of hot acetonitrile
4. waitin an ice-bath for 1 hour
5. filtrationBy filtration