HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → (R/S)-2-(3-acetoxy-2-oxo-1-pyrrolidinyl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | 1-Pyrrolidineacetamide, 3-hydroxy-2-oxo-, (+-)- | HCID 3069854 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | (R/S)-2-(3-acetoxy-2-oxo-1-pyrrolidinyl)acetamide | HCID 19817648 | — |
Reaction Steps
1.5 g of (R/S)-2-(3-hydroxy-2-oxo-1-pyrrolidinyl)acetamide are heated to reflux for 20 minutes with 13.5 ml of acetyl chloride and 25 ml of chloroform. The mixture is evaporated. The residue is treated four times with toluene and in each case again evaporated. There is obtained (R/S)-2-(3-acetoxy-2-oxo-1-pyrrolidinyl)acetamide which melts at 116°-117° after crystallization from diethyl ether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04650878 |
| Source dataset | uspto-grants-1987_03 |
| ORD ID | ord-f3cfc36c05a347a6819e34b8e4ad4b93 |
| Source note | uspto-grants-1987_03 |