Tetrahydrofuran → HCID 13398955, compound

Participants

Reaction Conditions

Reaction Steps

211 g (1 mol) of 5-morpholinonon-4-ene were dissolved in 1 liter of tetrahydrofuran. First 129.5 g (1 mol) of amidosulfonyl chloride in 300 ml of tetrahydrofuran and then 101 g (1 mol) of triethylamine were added dropwise to the solution, cooled to -40° C. The mixture was left to warm up to 20° C. and the precipitated triethylammonium hydrochloride was filtered off. The solvent was then distilled off and the residue was stirred for one hour with a mixture of 1 liter of methylene chloride and 250 ml of 2N hydrochloric acid. The organic phase was separated off, dried with sodium sulfate and distilled. This gave 152.3 g (65% of theory) of a colorless oil of boiling point 135°-138° C. at 0.3 mbar.

Provenance & Evidence