Dimethylamine → HCID 20213092, compound

Participants

Reaction Steps

A solution of 3-cyano-3,3-diphenyl-2-ethylpropionyl chloride (0.1 mol prepared from 0.1 mol of the acid as described above) in 100 ml of methylen chloride was added dropwise while stirring to a mixture of 65 ml of 33% aqueous dimethylamine (ca. 0.5 mol) and 100 g of crushed ice. The mixture was stirred for 1 hour at room temperature, whereupon the organic phase was separated and washed with dilute hydrochloric acid. After drying over magnesium sulphate, filtration and evaporation, the residue was crystallized from a mixture of methylene chloride and ether. Yield: 28 g (88%) of the amide as a white crystalline substance melting at 170°-172° C.

Provenance & Evidence