HCID 178418361, compound → HCID 178444260, compound

Participants

Reaction Steps

A solution of 0.214 g of 4'-[trans-4-[2-(4'-(trans-4-pentylcyclohexyl)-4-biphenylyl)vinyl]cyclohexyl]-4-biphenylcarbonitrile in 200 ml of tetrahydrofuran was treated with 52.5 mg of palladium/carbon (5%) and hydrogenated at room temperature until the hydrogen uptake came to a stand-still (1.75 hours). The reaction mixture was subsequently gassed with nitrogen and suction filtered (rinsing with hot tetrahydrofuran). After concentrating the filtrate in vacuo and drying at 50° C. under a water-jet vacuum there was obtained 0.310 g of colourless, solid 4'-[trans-4-[2-(4'-(trans-4-pentylcyclohexyl)-4-biphenylyl)ethyl]cyclohexyl]-4-biphenylcarbonitrile which still contained solvent. Recrystallization from tetrahydrofuran gave colourless needles with (S-N) 194.5° C. and cl.p. (N-I) 440° C.

Provenance & Evidence