Phosphorus tribromide → HCID 13840545, compound

HRID 1906360Notes

Reaction equation

HRID 1906360 reaction equation
[C:1]([CH:5](O)[C:6]([CH3:9])([CH3:8])[CH3:7])([CH3:4])([CH3:3])[CH3:2].P(Br)(Br)[Br:12]>C1C=CC=CC=1>[C:1]([CH:5]([Br:12])[C:6]([CH3:9])([CH3:8])[CH3:7])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 24614Phosphorus tribromideHCID 1397902,2,4,4-Tetramethylpentan-3-ol

Product 1

HCID 13840545HCID 13840545, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent2×

Conditions

Temperature
0 °C

Procedure

The alcohol is dissolved in benzene and stirred at 0° C. under argon. A solution of phosphorus tribromide in benzene is added and the mixture is stirred for 2 hours and then heated to 60° C. for 4 hours. The mixture is cooled, poured into ice and extracted with ether. The organic layer is washed with saturated NaHCO3, dried over MgSO4 and evaporated to give di-t-butylmethyl bromide.

Workup

  1. stirringthe mixture is stirred for 2 hours
  2. temperatureheated to 60° C. for 4 hours
  3. temperatureThe mixture is cooled
  4. additionpoured into ice
  5. extractionextracted with ether
  6. washThe organic layer is washed with saturated NaHCO3
  7. dry with materialdried over MgSO4
  8. customevaporated

Sources & evidence

ORD record
ord-e6c58c38dbfc4437b4b8a9e2bb60053a
Source dataset
uspto-grants-1987_03
Patent number
US04652457

Reaction notes

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