p-Toluenesulfonic acid → HCID 13504836, compound

Participants

Reaction Steps

A mixture of 2-[4-(trifluoromethyl)benzoyl]cyclohexanone, 5.4 g, 0.02 mole, with 2.28 g, 0.04 mole of azetidine and 25 mg of p-toluenesulfonic acid in 50 ml of benzene was refluxed for 17 hr using a Soxhlet device containing 50 g of 3 A molecular sieves. The resulting solution was evaporated, the residue was dissolved in 75 ml of ethanol and hydrogenated in the presence of 0.5 g of platinum dioxide (PtO2) at an initial pressure of 54 psig for 1.5 hr. The mixture was filtered, cooled in ice and treated with 5.4 g of sodium borohydride (NaBH4) and stirred at room temperature for 16 hr. The mixture was then evaporated, the residue taken up in a water/diethyl ether mixture, the ether extract being separated and washed with saturated sodium chloride solution, dried with magnesium sulfate and evaporated. Trituration of the residue with diethyl ether gave 0.76 g (plus filtrate) of the N-[2-[[4 -(trifluoromethyl)phenyl](hydroxy)methyl]cyclohexyl]azetidine as a colorless solid, mp 163°-165° C., which was raised to 167°-168° C. on recrystallization from methanol. The UV λmax(ε)216-(9,550), 252(382), 258(442), 263(411), 258(307). The IR and Mass spectral analyses were consistent. The NMR (CDCl3) indicated that the product contained a mixture of two diastereoisomers. δ7.6-7.4 (m, 5H, aromatic) 5.1 (m, 1H, HC--O) 2.7 (m, 1H, CH--N) 2.2-1.9 (m, 3H, CH'C--O and C--CH2 --C of azetidine) 1.9-0.9 (m, 8H, CH2 's).

Provenance & Evidence