Ethyl Acetoacetate → HCID 13799837, compound

Participants

Reaction Steps

A mixture of 20 g (0.16 mol) of 1-hydroxyethyl-2-oxo-pyrrolidine, 40 g (0.31 mole) of ethyl acetoacetate and 100 mg of sodium was heated at 140°-150° C. for six hours. Residual ethanol was removed in vacuo and the resultant oil was kugelrohr distilled (200° C./1 mm) to give 1.38 g (40%) of the product. NMR: (CDCl3) δ 2.1 (7H, m), 3.4 (6H, m) 4.1 (2H, t)

Provenance & Evidence