Acetyl chloride → HCID 13799846, compound

Participants

Reaction Steps

A suspension of sodium hydride (2.64 g, 0.11 mole) in 100 ml dry N,N'-dimethylformamide was heated dropwise with a solution of 2-(4-methylsulfonylphenyl)-3-(4-fluorophenyl)-1H-pyrrole (31.56 g, 0.1 mole) in 200 ml dry N,N'-dimethylformamide and stirred for one hour at room temperature. The mixture was then treated dropwise with acetyl chloride (7.9 g, 0.1 mole). The mixture was stirred for three hours and concentrated in vacuo. The residue was triturated with water, collected by filtration, dried, and column chromatographed on silica gel with toluene-ethyl acetate (3:2) as the mobile phase. The product was collected in 25% yield; m.p. 211°-214°.

Provenance & Evidence