Tert-Butylamine → HCID 13823540, compound

Participants

Reaction Steps

A solution of 3.75 g (0.01 mole) of 3-iodo-4-(oxiranylmethoxy)benzamide and 10.5 ml (0.1 mole) of t-butylamine in 7 ml of sulfolane was heated at 90° C. in an autoclave. After 2 hr the vessel was cooled and the t-butylamine was evaporated in vacuo. The residue was crystallized from CH2Cl2 /CH3CN to give 4.0 g (100% yield) of 4-[2-hydroxy-3-[(1,1-dimethylethyl)amino]propoxy]-3-iodobenzamide as a white crystalline solid, mp 111°-114° C.

Provenance & Evidence