HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiourea → HCID 13671422, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiourea | HCID 2723790 | — |
| Reactant | HCID 13671421 | HCID 13671421 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 13671422 | HCID 13671422 | 79.2% |
Reaction Steps
To a solution of 2-(chloroacetyl)malonic acid diethyl ester in ethanol (8 parts) is added thiourea (1.9 equivalents). After stirring at room temperature for 2 hours, the mixture is let stand overnight. The reaction mixture is concentrated, diluted with water, and neutralized with aqueous sodium hydrogen carbonate to give 2-(2-amino-4-thiazolyl)malonic acid diethyl ester. Yield: 79.2%. mp. 99.5°-100.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04652652 |
| Source dataset | uspto-grants-1987_03 |
| ORD ID | ord-3cf107c935974d3da058b22af749bd0a |
| Source note | uspto-grants-1987_03 |