Dimethyl itaconate → HCID 20212281, compound

Participants

Reaction Steps

16.8 g of finely powdered 2-mercaptobenzothiazole are suspended in 150 ml of 70% sulfuric acid and 16.6 g of dimethyl itaconate are added dropwise at 0°-10° in the course of half an hour, with stirring. After further 16 hours at 0°-10°, the reaction mixture is poured into ice water and extracted with ethyl acetate. The organic phase is separated, dried and the solvent is evapourated. The solid residue is recristallied from cyclohexane yielding dimethyl 3-(benzothiazol-2-ylthio)-propane-1,2-dicarboxylate, melting at 46°-47°.

Provenance & Evidence