HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(3-aminopropyl)pyridin-2-amine → 5-(4-Chlorobenzyl)-2-[3-(pyrid-2-ylamino)propylamino]-4-pyrimidone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(3-aminopropyl)pyridin-2-amine | HCID 10606924 | — |
| Reactant | 5-(4-Chlorobenzyl)-2-methylthiopyrimid-4-one | HCID 12945980 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-(4-Chlorobenzyl)-2-[3-(pyrid-2-ylamino)propylamino]-4-pyrimidone | HCID 20212235 | — |
Reaction Steps
2-(3-Aminopropylamino)pyridine (0.91 g) and 5-(4-chlorobenzyl)-2-methylthio-4-pyrimidone (1.33 g) were fused together on a oil bath at 160° C. for 2.5 hr. The mixture was dissolved in hot ethanol. Cooling afforded a white solid which on recrystallisation from ethanol gave 5-(4-chlorobenzyl)-2-[3-(pyrid-2-ylamino)propylamino]-4-pyrimidone, (1.24 g; 67%) m.p. 168°-71° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04652650 |
| Source dataset | uspto-grants-1987_03 |
| ORD ID | ord-d8371f87dd6f442cafd4a3428a34aa48 |
| Source note | uspto-grants-1987_03 |