5-(4-Chlorobenzyl)-2-methylthiopyrimid-4-one → HCID 53925041, compound

HRID 1906550Notes

Reaction equation

HRID 1906550 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][NH:5][C:6]1[C:11]([Cl:12])=[CH:10][CH:9]=[CH:8][N:7]=1.[Cl:13][C:14]1[CH:29]=[CH:28][C:17]([CH2:18][C:19]2[C:20](=[O:27])[NH:21][C:22](SC)=[N:23][CH:24]=2)=[CH:16][CH:15]=1>N1C=CC=CC=1>[Cl:13][C:14]1[CH:15]=[CH:16][C:17]([CH2:18][C:19]2[C:20](=[O:27])[NH:21][C:22]([NH:1][CH2:2][CH2:3][CH2:4][NH:5][C:6]3[C:11]([Cl:12])=[CH:10][CH:9]=[CH:8][N:7]=3)=[N:23][CH:24]=2)=[CH:28][CH:29]=1

Participants

4

Reactant 2

HCID 129459805-(4-Chlorobenzyl)-2-methylthiopyrimid-4-oneHCID 14397355HCID 14397355, compound

Product 1

HCID 53925041HCID 53925041, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

2-(3-Aminopropylamino)-3-chloropyridine (1 g) and 5-(4-chlorobenzyl)-2-methylthio-4-pyrimidone (1.3 g) were heated together under reflux in pyridine (20 ml) for 48 hr. The mixture was stripped and recrystallised from dimethyl formamide/ethanol/water to give 5-(4-chlorobenzyl)-2-[3-(3-chloropyrid-2-ylamino)propylamino]-4-pyrimidone 0.7H2O, (1.55 g; 76%) m.p. 180°-81° C.

Workup

  1. customrecrystallised from dimethyl formamide/ethanol/water

Sources & evidence

ORD record
ord-d5a854730b174dda8ab7aab79d94bb88
Source dataset
uspto-grants-1987_03
Patent number
US04652650

Reaction notes

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