Toluene → HCID 13647623, compound

HRID 1906557Notes

Reaction equation

HRID 1906557 reaction equation
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][C:7](=[O:11])[NH:8]2)=[CH:4][C:3]=1[CH3:12].ClS([N:17]=[C:18]=[O:19])(=O)=O.C1(C)C=CC=CC=1>O>[F:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][C:7](=[O:11])[N:8]2[C:18]([NH2:17])=[O:19])=[CH:4][C:3]=1[CH3:12]

Participants

5

Reactant 3

HCID 1140TolueneHCID 70918Chlorosulfonyl isocyanateHCID 135656696-Fluoro-1,3-dihydro-5-methyl-2H-indol-2-one

Product 1

HCID 13647623HCID 13647623, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Following the procedure of Example 2, the title compound was prepared from 6-fluoro-5-methyl-2-oxindole (1.0 g, 6.0 mmole), chlorosulfonyl isocyanate (1.03 g, 7.3 mmole), toluene (30 ml). Water (5 ml) was used for the hydrolysis step. Yield=0.58 g, 46%. M.P. 200°-203° C.

Sources & evidence

ORD record
ord-0a03076cafa74484af7734ad1327a502
Source dataset
uspto-grants-1987_03
Patent number
US04652658

Reaction notes

Loading…